Volume 1, Issue 1 (7-2015)                   tjpm 2015, 1(1): 19-27 | Back to browse issues page

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Sharifi A, Naghsh N, Razmi N. Evaluation of the Antioxidant Effects of Green Tea (Camellia sinensis) on Male Albino Mice poisoned with Thioacetamide. tjpm. 2015; 1 (1) :19-27
URL: http://tjpm.mazums.ac.ir/article-1-3444-en.html
PhD. of Animal Physiology, Associate Professor and Faculty Member of Islamic Azad University, Falavarjan Branch, Isfahan, Iran
Abstract:   (2218 Views)
Background & Objectives: Effects of free radicals and reactive oxygen species (ROS) on biological systems have been one of the most important medical concerns. Production of free radicals and ROS is inherent to aerobic life. This study aimed to investigate the antioxidant effects of green tea (camellia sinensis) on male Albino mice poisoned with thioacetamide. Materials and Methods: In this study, thioacetamide was injected intraperitoneally at doses of 100 and 150 mg/kg. In addition, enzyme activity of catalase (CAT) and glutathione peroxidase (GPx), as well as the concentration of malondialdehyde (MDA) as the main source of antioxidants, were measured in all the study groups. Results: There was a significant increase in the activities of CAT and GPx, while a significant decrease was observed in the level of MDA in the mice receiving combined green tea and thioacetamide compared to the recipients of thioacetamide alone (P<0.05). Conclusion: According to the results of this study, the antioxidant properties of green tea are associated with the presence of a polyphenol called catechin in this plant.
Full-Text [PDF 442 kb]   (908 Downloads)    
Type of Study: Research(Original) | Subject: طب سنتی
Received: 2015/07/15 | Accepted: 2015/07/15 | Published: 2015/07/15

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